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For the last 50 weeks, Carlos Alcaraz knew the exact date and time he would walk back on Centre Court to open the defense of his Wimbledon title and the Spaniard kept his goose bumps in check on Monday to book his place in the second round.

While injury woes have plagued many of those who have also hoisted the Challenge Cup in recent years -- with question marks over the participation of Novak Djokovic and Andy Murray -- Alcaraz showed his was fighting fit despite a less than ideal build-up to the grass court major.

The third seed, who admitted he even gets nervous practicing on the spiritual home of grass-court tennis, beat Estonian qualifier Mark Lajal 7-6 (3), 7-5, 6-2 on an overcast day in southwest London.

"Stepping on this court, it's the most beautiful court I've played on. I still get nerves when I'm playing here," Alcaraz, whose Queen's Club title defense ended with an early exit last month, said courtside.

"I played for 45 minutes here on Thursday and it's the first time I get nervous practicing. I'm glad and I'm a privileged guy to play on this court.

"When I walk around, I get goose bumps. I remember last year and that was a great feeling."

Fans flocking to the All England Club on Tuesday will be hoping that seven-time champions Djokovic and Murray, who ended Britain's 77-year wait for a men's Wimbledon champion when he won the first of his two titles in 2013, will both be fit enough to make their Centre Court dates.

While Djokovic had knee surgery last month, Murray is recovering from a procedure on his back just days ago. With this year's tournament expected to be his Wimbledon swan song, he is desperately hoping he can write the ending of his own script with one final rousing run on court rather than off it.

Twice French Open runner-up Casper Ruud was another player delighted to be back on court after he was hit by a parasitic infection that kept him in bed for almost two weeks following his run to the Roland Garros semifinals last month.

Ruud matched his best result at the championships after he reached the second round by defeating Australian qualifier Alex Bolt 7-6, 6-4, 6-4.

Fifth seed Daniil Medvedev, beaten in the semifinals last year by Alcaraz, produced an assured 6-3, 6-4, 6-2 win over American Aleksandar Kovacevic.

Top-ranked Jannik Sinner is set to play Yannick Hanfmann on Monday as well. Unseeded Canadian Denis Shapovalov was a winner earlier Monday with a 6-1, 7-5, 6-4 victory over No. 19 Nicolas Jarry.

Information from Reuters was used in this report.